Testosterone Replacement Therapy (TRT) has long been a cornerstone treatment for men with low testosterone levels, or hypogonadism. Yet one of the biggest questions surrounding TRT has been its impact on heart health. Is testosterone therapy safe for men with cardiovascular risk factors? Thanks to new research from the New England Journal of Medicine (NEJM), we now have clearer answers.
The Cardiovascular Concerns Around TRT
For years, studies presented conflicting views. Some observational data linked TRT to a higher risk of heart attacks, while others found no connection—or even a potential benefit. This confusion left many men uncertain about whether TRT could compromise their cardiovascular health.
Key Findings from the NEJM Study
In a rigorously designed clinical trial, researchers followed over 5,000 men between the ages of 45 and 80 who had low testosterone and either established cardiovascular disease or significant risk factors. Participants received either testosterone gel or a placebo and were tracked for the occurrence of major adverse cardiovascular events (MACE)—including heart attacks, strokes, and cardiovascular death.
The results were reassuring: testosterone therapy was found to be noninferior to placebo, meaning it did not increase the risk of cardiovascular events. This study represents one of the most comprehensive and well-controlled investigations into TRT and heart health to date.
Implications for Men Considering TRT
The takeaway? If you’re experiencing symptoms of low testosterone—such as reduced energy, low libido, or muscle loss—you no longer have to weigh those concerns against outdated fears of cardiovascular risk. With proper medical oversight, TRT is considered safe from a heart health perspective.
It’s also important to note that all participants in the NEJM study were monitored closely and treated using standardized protocols. That reinforces the need for individualized medical supervision when starting TRT.
Why This Research Matters
This study marks a turning point in how providers and patients understand TRT. It helps dispel lingering doubts and allows more men to consider this therapy as a safe and effective solution for hormonal imbalance, particularly when symptoms are significantly impacting quality of life.
Vybrant Health and Wellness: A Safe Path to Hormone Optimization
At Vybrant Health and Wellness, we specialize in comprehensive hormone evaluations and personalized testosterone therapy. We assess not just hormone levels, but also cardiovascular health, lifestyle factors, and long-term wellness goals.
We’re here to guide you through every step—safely and effectively.
Your Health, Your Future
Heart health is critical—but so is feeling energized, strong, and mentally sharp. The latest research shows that you don’t have to sacrifice one for the other. Testosterone therapy, when prescribed responsibly, offers men the chance to reclaim vitality without increasing cardiovascular risk.
If you’re ready to take the next step in your wellness journey, reach out to Vybrant Health and Wellness. Let’s optimize your health safely—starting with a thorough consultation.
Read more:
Cardiovascular Safety of Testosterone-Replacement Therapy
TRAVERSE Study Supports Cardiovascular Safety of Testosterone Therapy When Used as Indicated